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Founded in 1849, Pfizer Inc. reported revenues of $100.3 billion and net income of $31.372 billion in 2022, a 43% increase from the previous year. Headquartered in New York, Pfizer is a science-based, innovative, patient-first biopharmaceutical company. Pfizer's goal is to "bring breakthrough innovations to patients that change their lives.

GlaxoSmithKline (GSK) is a global pharmaceutical company founded in December 2000 as a result of the merger of Glaxo Wellcome and SmithKline Beecham, headquartered in London, UK. It specializes in the development of new drugs and vaccines, with revenues of £29.324 billion in 2022, and products in markets around the world.

Founded in 1896, Roche is one of the world's leading R&D-based, innovation-driven healthcare companies in pharmaceuticals and diagnostics. According to Drug R&D Cloud, there are only two imported ADC drugs in China, and Roche's emtricizumab (trade name "Herceptin") is one of them, which has been approved for marketing in January 2020 by the State Drug Administration.

A global leader in scientific services, dedicated to helping customers make the world healthier, cleaner and safer. The company has annual revenues of more than $20 billion and employs approximately 65,000 people worldwide.

Bristol-Myers Squibb is a global biopharmaceutical company dedicated to providing patients with innovative medicines to treat serious and challenging diseases. Globally, Bristol-Myers Squibb has one of the industry's richest and most promising pipelines, introducing breakthrough innovations in oncology, hematology, immunology and fibrosis, and cardiovascular disease. The company also has drug discovery and development capabilities in three major areas: chemical, biologics and cellular therapies.